Effects of Cerebrolysin on moderate cognitive impairments in cerebral vascular insufficiency (a clinical-electrophysiological study)

被引:24
作者
Damulin I.V. [1 ]
Koberskaya N.N. [1 ]
Mkhitaryan É.A. [1 ]
机构
[1] Department of Nervous Diseases, I. M. Sechenov Moscow Medical Academy, Moscow
关键词
300 cognitive evoked potentials; Cerebral vascular insufficiency; Cerebrolysin; Impairment of cognitive functions;
D O I
10.1007/s11055-008-9014-5
中图分类号
学科分类号
摘要
The efficacy of treatment with cerebrolysin was studied in 40 patients with cerebral vascular insufficiency. Cerebrolysin (20 daily i.v. infusions of 10 ml in 200 ml of physiological saline) was found to be an effective means of treating this group of patients. Courses of cerebrolysin treatment decreased the severity of memory and attention impairments, improving the overall cognitive status of the patients. Clinical observations and neuropsychological testing were supported by electrophysiological results, in terms of the P300 cognitive evoked potential. The effects of treatment at the doses used here were delayed and were seen three months after completion of treatment. © Springer Science+Business Media, Inc. 2008.
引用
收藏
页码:639 / 645
页数:6
相关论文
共 41 条
[1]  
Vereshchagin N.V., Lebedeva N.V., Mild forms of multi-infarct dementia: Efficacy of cerebrolysin, Sov. Med., 11, pp. 6-8, (1991)
[2]  
Vilenskii B.S., Stroke, (1995)
[3]  
Vilenskii B.S., Semenova G.M., Shirokov E.A., Use of cerebrolysin in ischemic stroke, Zh. Nevrol. Psikhiat., 99, 4, pp. 65-69, (1999)
[4]  
Windisch M., Cerebrolysin - New results supporting multilateral actions, Third International Symposium on Cerebrolysin, pp. 81-106, (1991)
[5]  
Gnezditskii V.V., Evoked Potentials in Clinical Practice, (2003)
[6]  
Gusev E.I., Skvortsova V.I., Brain Ischemia, (2001)
[7]  
Damulin I.V., Use of cerebrolysin in vascular dementia and Alzheimer's disease, Ros. Med. Zh., 25, pp. 1150-1156, (2002)
[8]  
Zakharov V.V., Yakhno N.N., Cognitive impairments in the aged and elderly, Methods for Doctors, (2005)
[9]  
Zakharov V.V., Damulin I.V., Diagnosis and Treatment of Impairments to Memory and Other Higher Brain Functions in the Elderly, (1997)
[10]  
Zenkov L.R., Ronkin M.A., Functional Diagnosis of Nervous Diseases, (2004)