Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia

被引：5

作者：

Liang Hui

Chen Hu

Gao Yin

Cai Ding-fang

机构：

[1] Fudan University,Department of Integrated TCM and Western Medicine, Huashan Hospital

[2] The First affiliated Hspital of Medical College of Zhejiang University,Department of neurology

来源：

Chinese Journal of Integrative Medicine | 2003年 / 9卷 / 4期

关键词：

muscone; cerebral ischemia; neuronal glutamate transporter; neuroprotection;

D O I：

10.1007/BF02838617

中图分类号：

学科分类号：

摘要：

Objective: To investigate muscone’s neuroprotective action and its mechanism in rats with acute cerebral ischemic injury.Methods: Rat focal ischemic model of middle cerebral artery occlusion (MCAO) was established by thread inserting method. TTC staining, RT-PCR and Western blot analysis were used to study the effects of muscone on infracted volume, EAAClmRNA and protein levels.Results: Infarcted volume in the muscone treated group was significantly lower than that in the model control group. Compared with normal group, EAAC1 mRNA level increased in the model control group at 6 and 24 hrs, and protein level increased at 24 hrs after modelling, muscone could reduce the increased expression in model rats.Conclusion: Muscone possesses the action of neuroprotection, its mechanism may be related to reduction of EAAC1 and protein expressions.

引用

页码：285 / 288

页数：3

共 19 条

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