Pathogenic interactions between alcohol and hepatitis C

被引：28

作者：

Gyongyi Szabo

机构：

[1] Hepatology and Liver Center, Division of Gastroenterology, Univ. of Massachusetts Med. School, Worcester, MA 01605

来源：

Current Gastroenterology Reports | 2003年 / 5卷 / 1期

关键词：

Alcoholic Liver Disease; Hepatocyte Apoptosis; Dendritic Cell Control; Allostimulatory Capacity;

D O I：

10.1007/s11894-003-0014-x

中图分类号：

学科分类号：

摘要：

Alcohol is the most commonly abused substance in the United States, and alcohol abuse leads to alcoholic liver disease, a long recognized major public health concern. The high prevalence of chronic hepatitis C virus (HCV) infection, along with the clinical observation that HCV infection is common in alcoholic patients presenting with liver disease, has directed attention to the interaction between alcohol and HCV infection. Clinical studies have identified alcohol use as an independent risk factor for progression of fibrosis in chronic HCV infection. Experimental evidence suggests additive inhibitory effects between HCV and alcohol on antiviral immune responses. In addition, specific pathways have been identified by which HCV core protein and alcohol interact to activate hepatocytes. Nonspecific inflammatory cell recruitment and proinflammatory cytokine activation have also been implicated in both alcohol- and HCV-induced liver diseases. Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease. Copyright © 2003 by Current Science Inc.

引用

页码：86 / 92

页数：6

共 50 条

[1]

Liang J.T., Rehermann D., Seeff L.B., Hoofnagle J.H., Pathogenesis, natural history, treatment, and prevention of hepatitis C, Ann. Intern. Med., 132, pp. 296-305, (2000)

[2]

Schiff E.R., The alcoholic patient with HCV infection, Am. J. Med., 107, (1999)

[3]

Pessione F., Degos F., Marcellin P., Et al., Effect of alcohol consumption on serum hepatitis c virus RNA and histological lesions in chronic HCV, Hepatology, 27, pp. 1717-1722, (1998)

[4]

Corrano G., Arico S., Independent and combined action of hepatitis c virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis, Hepatology, 27, pp. 914-919, (1998)

[5]

Wiley T., McCarthy M., Breid L., Et al., Impact of alcohol on the histological and clinical progression of hepatitis C infection, Hepatology, 28, pp. 805-809, (1998)

[6]

Vento S., Cainelli F., Does hepatitis C virus cause severe liver disease only in people who drink alcohol?, Lancet Infect. Dis., 2, pp. 303-309, (2002)

[7]

Poynard T., Ratziu V., Charlotte F., Et al., Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C, J. Hepatol., 34, pp. 730-739, (2001)

[8]

Westin J., Lagging L.M., Spak F., Et al., Moderate alcohol intake increases fibrosis progression in untreated patients with HCV infection, J. Viral Hepat., 9, pp. 235-241, (2002)

[9]

Cromie S.L., Jenkins P.J., Bowden D.S., Dudley F.J., Chronic hepatitis C: Effect of alcohol on hepatic activity and viral titre, J. Hepatol., 25, pp. 821-826, (1996)

[10]

Levy L., Renard C., Wei Y., Buendia M., Genetic alterations and oncogenic pathways in hepatocellular carcinoma, Ann. N. Y. Acad. Sci., 963, pp. 21-36, (2002)

← 1 2 3 4 5 →