Synaptic organization of the glomerulus in the main olfactory bulb: Compartments of the glomerulus and heterogeneity of the periglomerular cells

被引：94

作者：

Kosaka K. ^{[1
]}

Kosaka T. ^{[2
]}

机构：

[1] School of Health Sciences, Faculty of Medicine, Kyushu University, Higashiku

[2] Department of Anatomy and Neurobiology, Graduate School of Medicial Sciences, Kyushu University, Higashiku

来源：

Anatomical Science International | 2005年 / 80卷 / 2期

基金：

日本学术振兴会;

关键词：

Calcium-binding proteins; GABA; Gap junction; Interneuron; Synapse;

D O I：

10.1111/j.1447-073x.2005.00092.x

中图分类号：

学科分类号：

摘要：

According to the combinatorial receptor and glomerular codes for odors, the fine tuning of the output level from each glomerulus is assumed to be important for information processing in the olfactory system, which may be regulated by numerous elements, such as olfactory nerves (ONs), periglomerular (PG) cells, centrifugal nerves and even various interneurons, such as granule cells, making synapses outside the glomeruli. Recently, structural and physiological analyses at the cellular level started to reveal that the neuronal organization of the olfactory bulb may be more complex than previously thought. In the present paper, we describe the following six points of the structural organization of the glomerulus, revealed by confocal laser scanning microscopy and electron microscopy analyses of rats, mice and other mammals: (i) the chemical heterogeneity of PG cells; (ii) compartmental organization of the glomerulus, with each glomerulus consisting of two compartments, the ON zone and the non-ON zone; (iii) the heterogeneity of PG cells in terms of their structural and synaptic features, whereby type 1 PG cells send their intraglomerular dendrites into both the ON and non-ON zones and type 2 PG cells send their intraglomerular dendrites only into the non-ON zone, thus receiving either few synapses from the ON terminals, if present, or none at all; (iv) the spatial relationship of mitral/tufted cell dendritic processes with ON terminals and PG cell dendrites; (v) complex neuronal interactions via chemical synapses and gap junctions in the glomerulus; and (vi) comparative aspects of the organization of the main olfactory bulb.

引用

页码：80 / 90

页数：10

共 80 条

[1]

Baimbridge K.G., Miller J.J., Immunohistochemical localization of calcium-binding protein in the cerebellum, hippocampal formation and olfactory bulb of the rat, Brain Res., 245, pp. 223-239, (1982)

[2]

Bennett M.V.L., Zukin R.S., Electrical coupling and neuronal synchronization in the mammalian brain, Neuron, 41, pp. 495-511, (2004)

[3]

Bogan N., Brecha N., Gall C., Karten H.J., Distribution of enkephalin-like immunoreactivity in the rat main olfactory bulb, Neuroscience, 7, pp. 895-906, (1982)

[4]

Brinon J.G., Alonso J.R., Arevalo R., Garcia-Ojeda E., Lara J., Aijon J., Calbindin-D28K-positive neurons in the rat main olfactory bulb, Cell Tissue Res., 269, pp. 289-297, (1992)

[5]

Buck L., Axel R., A novel multigene family may encode odorant receptors: A molecular basis for odor recognition, Cell, 65, pp. 175-187, (1991)

[6]

Celio M.R., Calbindin D-28k and parvalbumin in the rat nervous system, Neuroscience, 35, pp. 375-475, (1990)

[7]

Chao T.I., Kasa P., Wolff J.R., Distribution of astroglia in glomeruli of the rat main olfactory bulb: Exclusion from the sensory subcompartment of neuropil, J. Comp. Neurol., 388, pp. 191-210, (1997)

[8]

Crosby E.C., Schnitzlein H.N., Comparative Correlative Neuroanatomy of the Vertebrate Telencephalon, (1982)

[9]

Davis B.J., Macrides F., Tyrosine hydroxylase immunoreactive neurons and fibers in the olfactory system of the hamster, J. Comp. Neurol., 214, pp. 427-440, (1983)

[10]

Davis B.J., Burd G.D., Macrides F., Localization of methionine-enkephalin, substance P, and somatostatin immunoreactivities in the main olfactory bulb of the hamster, J. Comp. Neurol., 204, pp. 377-383, (1982)

← 1 2 3 4 5 6 7 8 →