Differentiation of human γδ T cells towards distinct memory phenotypes

被引：64

作者：

Eberl, M

Engel, R

Beck, E

Jomaa, H

机构：

[1] Univ Giessen, Inst Biochem, D-35392 Giessen, Germany

[2] Jomaa Pharmaka GmbH, D-35392 Giessen, Germany

来源：

CELLULAR IMMUNOLOGY | 2002年 / 218卷 / 1-2期

关键词：

gamma delta T cells; V gamma 9/V delta 2 T cells; IL-21; interleukin-21; cytokines; memory; phosphoantigen; (E)-4-hydroxy-3-methyl-but-2-enyl; pyrophosphate; isoprenoid biosynthesis;

D O I：

10.1016/S0008-8749(02)00519-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vgamma9/Vdelta2 T cells comprise a small population of peripheral T cells responding towards the low molecular weight antigen, (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate (HMB-PP). HMB-PP-stimulated Vgamma9/Vdelta2 T cells proliferated, expressed CCL5/RANTES, and upregulated markers like CD16, CD25, CD69, and CD94, in the presence of either IL-15 or IL-21. Vgamma9/Vdelta2 T cells grown in the presence of IL-15 differentiated into an effector/memory population characterized by production of TNF-alpha, expression of CD45RO and CCR5, and lack of CD62L, CD81, and CCR7. In contrast, Vgamma9/Vdelta2 T cells grown with IL-21 differentiated into putative central memory CD45RO(+) T cells that did not produce TNF-alpha, IFN-gamma, or IL-4, and maintained expression of CD62L, CD81, and CCR7. (C) 2002 Elsevier Science (USA). All rights reserved.

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页码：1 / 6

页数：6

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