Neurofilaments and neurological disease

被引：146

作者：

Al-Chalabi, A

Miller, CCJ

机构：

[1] Kings Coll London, Dept Neurosci, London WC2R 2LS, England

[2] Kings Coll London, Dept Neurol, London WC2R 2LS, England

来源：

BIOESSAYS | 2003年 / 25卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1002/bies.10251

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by posttranslational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments.

引用

收藏

页码：346 / 355

页数：10

相关论文

共 101 条

[1] Glutamate slows axonal transport of neurofilaments in transfected neurons [J].

Ackerley, S ;

Grierson, AJ ;

Brownlees, J ;

Thornhill, P ;

Anderton, BH ;

Leigh, PN ;

Shaw, CE ;

Miller, CCJ .

JOURNAL OF CELL BIOLOGY, 2000, 150 (01) :165-175

[2] Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis [J].

Al-Chalabi, A ;

Andersen, PM ;

Nilsson, P ;

Chioza, B ;

Andersson, JL ;

Russ, C ;

Shaw, CE ;

Powell, JF ;

Leigh, PN .

HUMAN MOLECULAR GENETICS, 1999, 8 (02) :157-164

[3]

Bajaj NPS, 1997, J NEUROCHEM, V69, P737

[4] Late onset death of motor neurons in mice overexpressing wild-type peripherin [J].

Beaulieu, JM ;

Nguyen, MD ;

Julien, JP .

JOURNAL OF CELL BIOLOGY, 1999, 147 (03) :531-544

[5] Identification of phosphorylation sites on neurofilament proteins by nanoelectrospray mass spectrometry [J].

Betts, JC ;

Blackstock, WP ;

Ward, MA ;

Anderton, BH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (20) :12922-12927

[6] The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy [J].

Bomont, P ;

Cavalier, L ;

Blondeau, F ;

Hamida, CB ;

Belal, S ;

Tazir, M ;

Demir, E ;

Topaloglu, H ;

Korinthenberg, R ;

Tüysüz, B ;

Landrieu, P ;

Hentati, F ;

Koenig, M .

NATURE GENETICS, 2000, 26 (03) :370-374

[7]

Brownlees J, 2000, J CELL SCI, V113, P401

[8]

Chen JG, 2000, J CELL SCI, V113, P3861

[9]

Ching GY, 1999, J NEUROSCI, V19, P2974

[10] Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease [J].

Cleveland, DW ;

Bruijn, LI ;

Wong, PC ;

Marszalek, JR ;

Vechio, JD ;

Lee, MK ;

Xu, XS ;

Borchelt, DR ;

Sisodia, SS ;

Price, DL .

NEUROLOGY, 1996, 47 (04) :S54-S61

← 1 2 3 4 5 6 7 8 9 10 →