Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

被引：1364

作者：

Glinka, A

Wu, W

Delius, H

Monaghan, AP

Blumenstock, C

Niehrs, C

机构：

[1] Deutsch Krebsforschungszentrum, Div Mol Embryol, D-69120 Heidelberg, Germany

[2] Deutsch Krebsforschungszentrum, Div Appl Tumorvirol, D-69120 Heidelberg, Germany

[3] Deutsch Krebsforschungszentrum, Div Mol Biol Cell 1, D-69120 Heidelberg, Germany

来源：

NATURE | 1998年 / 391卷 / 6665期

关键词：

D O I：

10.1038/34848

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody Indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.

引用

页码：357 / 362

页数：6

共 46 条

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