Adams: Key components in EGFR signalling and development

被引：928

作者：

Blobel, CP

机构：

[1] Cornell Univ, Weill Med Coll, Hosp Special Surg, Arthrit & Tissue Degenerat Program, New York, NY 10021 USA

[2] Cornell Univ, Weill Med Coll, Hosp Special Surg, Cell Biol Program, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 01期

关键词：

D O I：

10.1038/nrm1548

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ADAM ( a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.

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页码：32 / 43

页数：12

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