The Efficacy of Iron Chelators for Removing Iron from Specific Brain Regions and the Pituitary-Ironing out the Brain

被引:28
作者
Crichton, Robert R. [1 ]
Ward, Roberta J. [2 ]
Hider, Robert C. [3 ]
机构
[1] Catholic Univ Louvain, Fac Sci, B-1348 Louvain La Neuve, Belgium
[2] Imperial Coll, Div Brain Sci, London W12 0NN, England
[3] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England
关键词
iron; chelation; neurodegenerative diseases; pituitary; brain; BETA-THALASSEMIA; ALZHEIMERS-DISEASE; SUBSTANTIA-NIGRA; PARKINSONS; OVERLOAD; DEFERASIROX; MRI; DESFERRITHIOCIN; DESFERRIOXAMINE; NEUROMELANIN;
D O I
10.3390/ph12030138
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Iron chelation therapy, either subcutaneous or orally administered, has been used successfully in various clinical conditions. The removal of excess iron from various tissues, e.g., the liver spleen, heart, and the pituitary, in beta thalassemia patients, has become an essential therapy to prolong life. More recently, the use of deferiprone to chelate iron from various brain regions in Parkinson's Disease and Friederich's Ataxia has yielded encouraging results, although the side effects, in <2% of Parkinson's Disease(PD) patients, have limited its long-term use. A new class of hydroxpyridinones has recently been synthesised, which showed no adverse effects in preliminary trials. A vital question remaining is whether inflammation may influence chelation efficacy, with a recent study suggesting that high levels of inflammation may diminish the ability of the chelator to bind the excess iron.
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页数:13
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