Involvement of tetrodotoxin-sensitive sodium channels in rat growth hormone secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP)

被引：18

作者：

Murakami, Y ^{[1
]}

Tanaka, J ^{[1
]}

Koshimura, K ^{[1
]}

Kato, Y ^{[1
]}

机构：

[1] Shimane Med Univ, Dept Med, Div 1, Izumo, Shimane 693, Japan

来源：

REGULATORY PEPTIDES | 1998年 / 73卷 / 02期

关键词：

PACAP-38; tetrodotoxin; sodium channel; growth hormone; rat;

D O I：

10.1016/S0167-0115(97)01075-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and growth hormone-releasing hormone (GRH) stimulated growth hormone (GH) release from perfused rat anterior pituitary cells. Tetrodotoxin (TTX) blunted the GH release induced by PACAP-38 but not by GRH. Mefenamic acid, a blocker of non-selective cation channels, unaffected GH release elicited by PACAP-38 and GRH. These results suggest an involvement of TTX-sensitive Na+ channels but not Ca2+-activated nonselective cation channels in PACAP-38-induced GH secretion, and that post-receptor mechanisms for PACAP-38 are different from those activated by GRH. (C) 1998 Elsevier Science B.V.

引用

页码：119 / 121

页数：3

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