Cancer chemotherapy: A SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy

被引：22

作者：

Angenault, S

Thirot, S

Schmidt, F

Monneret, C

Pfeiffer, B

Renard, P

机构：

[1] Inst Curie, CNRS, UMR176, F-75248 Paris 05, France

[2] Lab Servier 1, F-92415 Courbevoie, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/S0960-894X(02)01080-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A glucuronide-based prodrug of SN-38 (7-etbyl-10-hydroxycamptothecin) has been synthesized for use in a Prodrug MonoTherapy Strategy (PMT). Since this prodrug is significantly less cytotoxic than SN-38 itself and efficiently releases the drug in vitro in the presence of beta-D-glucuronidase, it can be considered as an appropriate candidate for cancer treatment by a PMT strategy. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：947 / 950

页数：4

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