Homocysteine and pro-inflammatory cytokine concentrations in acute heart disease

被引：34

作者：

Gokkusu, Cahide ^{[1
]}

Tulubas, Feti ^{[1
]}

Unlucerci, Yesim ^{[1
]}

Ozkok, Elif ^{[2
]}

Umman, Berrin ^{[3
]}

Aydin, Makbule ^{[2
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkey

[2] Istanbul Univ, Inst Expt Med, Dept Neurosci, Istanbul, Turkey

[3] Istanbul Univ, Istanbul Fac Med, Dept Cariol, Istanbul, Turkey

来源：

CYTOKINE | 2010年 / 50卷 / 01期

关键词：

Homocysteine; Interleukin; Folate; Vitamin B12; Acute heart disease; C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; IL-2; RECEPTOR; PLASMA-LEVELS; RISK-FACTOR; INTERLEUKIN-6; HYPERHOMOCYSTEINEMIA; EXPRESSION; ANGINA;

D O I：

10.1016/j.cyto.2009.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation is involved in development and progression of atherosclerosis. Interleukin-2 (IL-2) and interleukin-6 (IL-6) have been correlated with various cardiovascular diseases. Hyperhomocysteinemia is an important risk factor for atherosclerosis and thrombotic disease. Recent studies have demonstrated that homocysteine (Hcy) enhances productions of several pro-inflammatory cytokines. In the light of these findings, we decided to determine if any relationship exists between IL-2 and IL-6, the pro-inflammatory cytokines, and total homocysteine (tHcy) in acute coronary syndrome (ACS). A total of 102 patients with ACS and 90 healthy subjects were included in the study. The levels of tHcy, IL-2 and IL-6 were higher and folic acid was lower in patients as compared with those of controls. Furthermore, data of the area under ROC plot for IL-2 demonstrated that IL-2 had higher sensitivity. These data suggest that enhanced inflammation may be associated with tHcy-related cardiovascular disease. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：15 / 18

页数：4

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