Definitions of enzyme function for the structural genomics era

被引：52

作者：

Babbitt, PC

机构：

[1] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(03)00028-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Questions are being asked about how enzyme function is described at the molecular level and the strengths and weaknesses of the EC system for this purpose. A new approach to describing enzyme function has been proposed that might improve our capabilities for functional inference for members of enzyme superfamilies.

引用

收藏

页码：230 / 237

页数：8

相关论文

共 58 条

[1] Evolution of enzymes in metabolism: A network perspective [J].

Alves, R ;

Chaleil, RAG ;

Sternberg, MJE .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 320 (04) :751-770

[2]

[Anonymous], 1992, ENZYME NOMENCLATURE

[3] Mechanistic diversity in a metalloenzyme superfamily [J].

Armstrong, RN .

BIOCHEMISTRY, 2000, 39 (45) :13625-13632

[4] A GRAPH-THEORETIC APPROACH TO THE IDENTIFICATION OF 3-DIMENSIONAL PATTERNS OF AMINO-ACID SIDE-CHAINS IN PROTEIN STRUCTURES [J].

ARTYMIUK, PJ ;

POIRRETTE, AR ;

GRINDLEY, HM ;

RICE, DW ;

WILLETT, P .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 243 (02) :327-344

[5]

Ashburner M, 2001, GENOME RES, V11, P1425

[6] The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step [J].

Asuncion, M ;

Blankenfeldt, W ;

Barlow, JN ;

Gani, D ;

Naismith, JH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) :8306-8311

[7]

Babbitt PC, 2001, ADV PROTEIN CHEM, V55, P1, DOI 10.1016/S0065-3233(01)55001-9

[8] The enolase superfamily: A general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids [J].

Babbitt, PC ;

Hasson, MS ;

Wedekind, JE ;

Palmer, DRJ ;

Barrett, WC ;

Reed, GH ;

Rayment, I ;

Ringe, D ;

Kenyon, GL ;

Gerlt, JA .

BIOCHEMISTRY, 1996, 35 (51) :16489-16501

[9] Understanding enzyme superfamilies - Chemistry as the fundamental determinant in the evolution of new catalytic activities [J].

Babbitt, PC ;

Gerlt, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :30591-30594

[10] Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis [J].

Baker, AS ;

Ciocci, MJ ;

Metcalf, WW ;

Kim, J ;

Babbitt, PC ;

Wanner, BL ;

Martin, BM ;

Dunaway-Mariano, D .

BIOCHEMISTRY, 1998, 37 (26) :9305-9315

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