Hepatocyte nuclear factor-4α mediates the stimulatory effect of peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

被引：59

作者：

Boustead, JN ^{[1
]}

Stadelmaier, BT ^{[1
]}

Eeds, AM ^{[1
]}

Wiebe, PO ^{[1
]}

Svitek, CA ^{[1
]}

Oeser, JK ^{[1
]}

O'Brien, RM ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Physiol & Mol Biophys, Sch Med, Nashville, TN 37232 USA

来源：

BIOCHEMICAL JOURNAL | 2003年 / 369卷 / 01期

关键词：

diabetes; gluconeogenesis; HNF-4; phosphoenolpyruvate carboxykinase;

D O I：

10.1042/BJ20021382

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4alpha.

引用

页码：17 / 22

页数：6

共 48 条

[1] PGC-l-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells [J].

Andersson, U ;

Scarpulla, RC .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) :3738-3749

[2] A RAPID MICROPREPARATION TECHNIQUE FOR EXTRACTION OF DNA-BINDING PROTEINS FROM LIMITING NUMBERS OF MAMMALIAN-CELLS [J].

ANDREWS, NC ;

FALLER, DV .

NUCLEIC ACIDS RESEARCH, 1991, 19 (09) :2499-2499

[3] Nuclear hormone receptors and gene expression [J].

Aranda, A ;

Pascual, A .

PHYSIOLOGICAL REVIEWS, 2001, 81 (03) :1269-1304

[4] Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states - Gene structure and 5'-flanking sequence [J].

Argaud, D ;

Zhang, Q ;

Pan, WS ;

Maitra, S ;

Pilkis, SJ ;

Lange, AJ .

DIABETES, 1996, 45 (11) :1563-1571

[5]

BARZILAI N, 1993, J BIOL CHEM, V268, P25019

[6] Nutrient regulation of gene expression by the sterol regulatory element binding proteins:: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo [J].

Bennett, MK ;

Osborne, TF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6340-6344

[7] Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells [J].

Canuto, RA ;

Ferro, M ;

Salvo, RA ;

Bassi, AM ;

Trombetta, A ;

Maggiora, M ;

Martinasso, G ;

Lindahl, R ;

Muzio, G .

BIOCHEMICAL JOURNAL, 2001, 357 :811-818

[8] Multiple promoter elements are required for the stimulatory effect of insulin on human collagenase-1 gene transcription -: Selective effects on activator protein-1 expression may explain the quantitative difference in insulin and phorbol ester action [J].

Chapman, SC ;

Ayala, JE ;

Streeper, RS ;

Culbert, AA ;

Eaton, EM ;

Svitek, CA ;

Goldman, JK ;

Tavaré, JM ;

O'Brien, RM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18625-18634

[9] The direct and indirect effects of insulin on hepatic glucose production in vivo [J].

Cherrington, AD ;

Edgerton, D ;

Sindelar, DK .

DIABETOLOGIA, 1998, 41 (09) :987-996

[10]

Chou Janice Yang, 2002, Current Molecular Medicine (Hilversum), V2, P121, DOI 10.2174/1566524024605798

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