Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke

被引：95

作者：

Brea, David ^{[1
]}

Sobrino, Tomas ^{[1
]}

Blanco, Miguel ^{[1
]}

Cristobo, Ivan ^{[1
]}

Rodriguez-Gonzalez, Raquel ^{[1
]}

Rodriguez-Yanez, Manuel ^{[1
]}

Moldes, Octavio ^{[1
]}

Agulla, Jesus ^{[1
]}

Leira, Rogelio ^{[1
]}

Castillo, Jose ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Hosp Clin Univ, Serv Neurol, Clin Neurosci Res Lab,Dept Neurol, Santiago De Compostela 15706, Spain

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2009年 / 47卷 / 12期

关键词：

acute stroke; neuron-specific enolase; outcome; S100; protein; BRAIN-DAMAGE; NEUROBIOCHEMICAL MARKERS; BIOCHEMICAL MARKERS; AMINO-ACIDS; INFARCT; PROTEIN; TRANSFORMATION; RELEASE; NSE;

D O I：

10.1515/CCLM.2009.337

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Neuron-specific enolase (NSE) and S100 protein are implicated in several brain injuries, including stroke. Our objective was to analyze the temporal profile and the clinical significance of NSE and S-100 in acute ischemic (IS) and intracerebral hemorrhage (ICH). Methods: We studied 224 patients with IS and 44 patients with ICH. Computerized tomography (CT) scans were performed to assess infarct volume. Stroke severity was evaluated using the National Institute of Health Stroke Scale (NIHSS), and functional outcome at 3 months with the modified Rankin Scale (mRS). Serum NSE and S100 protein were measured using an electrochemiluminescence-immunoassay. Results: Peak values were found at 72 h for NSE and at 24 h for S100 in IS. For ICH, peak values were found at 24 h for both NSE and S100. At these time intervals S100 and NSE correlated with the NIHSS score and were independently associated with poor outcome. Conclusions: High serum NSE and S100 are associated with poor outcome in IS, and high serum NSE is associated with poor outcome in ICH. These findings suggest the potential utility of NSE and S100 as prognostic markers for acute stroke. Clin Chem Lab Med 2009;47:1513-8.

引用

页码：1513 / 1518

页数：6

共 31 条

[1] Neuron-specific enolase as a marker for acute ischemic stroke: A systematic review [J].