Angiotensin-converting enzyme gene polymorphism in systemic hypertension

被引：36

作者：

Abbud, ZA ^{[1
]}

Wilson, AC ^{[1
]}

Cosgrove, NM ^{[1
]}

Kostis, JB ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, TONE Clin Ctr, New Brunswick, NJ 08903 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1998年 / 81卷 / 02期

关键词：

D O I：

10.1016/S0002-9149(97)00876-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We determined the angiotensin-converting enzyme (ACE) insertion/deletion genotype in 209 hypertensive individuals and in 100 matched normotensive controls. A significant association was detected between hypertension and the deletion/deletion (D/D) genotype of the ACE gene when the relation was adjusted for age, sex, and body mass index.

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收藏

页码：244 / 246

页数：3

相关论文

共 20 条

[1]

Appel Lawrence J., 1995, Annals of Epidemiology, V5, P119, DOI 10.1016/1047-2797(94)00056-Y

[2]

BERGE KE, 1994, CLIN GENET, V45, P169

[3] DELETION POLYMORPHISM IN THE GENE FOR ANGIOTENSIN-CONVERTING ENZYME IS A POTENT RISK FACTOR FOR MYOCARDIAL-INFARCTION [J].

CAMBIEN, F ;

POIRIER, O ;

LECERF, L ;

EVANS, A ;

CAMBOU, JP ;

ARVEILER, D ;

LUC, G ;

BARD, JM ;

BARA, L ;

RICARD, S ;

TIRET, L ;

AMOUYEL, P ;

ALHENCGELAS, F ;

SOUBRIER, F .

NATURE, 1992, 359 (6396) :641-644

[4] FREQUENCY OF A DELETION POLYMORPHISM IN THE GENE FOR ANGIOTENSIN-CONVERTING ENZYME IS INCREASED IN AFRICAN-AMERICANS WITH HYPERTENSION [J].

DURU, K ;

FARROW, S ;

WANG, JM ;

LOCKETTE, W ;

KURTZ, T .

AMERICAN JOURNAL OF HYPERTENSION, 1994, 7 (08) :759-762

[5] A DELETION POLYMORPHISM IN THE ANGIOTENSIN-CONVERTING ENZYME GENE IS NOT ASSOCIATED WITH CORONARY HEART-DISEASE IN AN AUSTRIAN POPULATION [J].

FRIEDL, W ;

KREMPLER, F ;

PAULWEBER, B ;

PICHLER, M ;

SANDHOFER, F .

ATHEROSCLEROSIS, 1995, 112 (02) :137-143

[6] Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension [J].

Gharavi, AG ;

Lipkowitz, MS ;

Diamond, JA ;

Jhang, JS ;

Phillips, RA .

AMERICAN JOURNAL OF CARDIOLOGY, 1996, 77 (15) :1315-1319

[7] THE ANGIOTENSIN-I CONVERTING ENZYME GENE AND PREDISPOSITION TO HIGH BLOOD-PRESSURE [J].

HARRAP, SB ;

DAVIDSON, HR ;

CONNOR, JM ;

SOUBRIER, F ;

CORVOL, P ;

FRASER, R ;

FOY, CJW ;

WATT, GCM .

HYPERTENSION, 1993, 21 (04) :455-460

[8] ASSOCIATION ANALYSIS OF A POLYMORPHISM OF THE ANGIOTENSIN CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION IN THE JAPANESE POPULATION [J].

HIGASHIMORI, K ;

ZHAO, Y ;

HIGAKI, J ;

KAMITANI, A ;

KATSUYA, T ;

NAKURA, J ;

MIKI, T ;

MIKAMI, H ;

OGIHARA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 191 (02) :399-404

[9] ANGIOTENSIN-I CONVERTING-ENZYME (ACE) GENE POLYMORPHISM AND ESSENTIAL-HYPERTENSION IN JAPAN - ETHNIC DIFFERENCE OF ACE GENOTYPE [J].

ISHIGAMI, T ;

IWAMOTO, T ;

TAMURA, K ;

YAMAGUCHI, S ;

IWASAWA, K ;

UCHINO, K ;

UMEMURA, S ;

ISHII, M .

AMERICAN JOURNAL OF HYPERTENSION, 1995, 8 (01) :95-97

[10] ABSENCE OF LINKAGE BETWEEN THE ANGIOTENSIN CONVERTING ENZYME LOCUS AND HUMAN ESSENTIAL-HYPERTENSION [J].

JEUNEMAITRE, X ;

LIFTON, RP ;

HUNT, SC ;

WILLIAMS, RR ;

LALOUEL, JM .

NATURE GENETICS, 1992, 1 (01) :72-75