New windows on the mechanism of action of KATP channel openers

被引：2

作者：

Ashcroft, FM

Gribble, FM

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

[2] Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QR, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

K-ATP channel openers are a diverse group of drugs with a wide range of potential therapeutic uses. Their molecular targets, the K-ATP channels, exhibit tissue-specific responses because they possess different types of regulatory sulfonylurea receptor subunits. It is well recognized that complex interactions occur between K-ATP channel openers and nucleotides, but the cloning of the K-ATP channel has introduced a new dimension to the study of these events and has furthered our understanding of the molecular basis of the action of K-ATP channel openers.

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收藏

页码：439 / 445

页数：7

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