A novel role for the Receptor for Advanced Glycation End-products in neural progenitor cells derived from adult SubVentricular Zone

被引：47

作者：

Meneghini, Vasco ^{[1
,2
]}

Francese, Maria Teresa ^{[1
,2
]}

Carraro, Lorenzo ^{[1
]}

Grilli, Mariagrazia ^{[1
,2
]}

机构：

[1] Univ Piemonte Orientate Avogadro, DiSCAFF, I-28100 Novara, Italy

[2] DFB Ctr, I-28100 Novara, Italy

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2010年 / 45卷 / 02期

关键词：

RAGE; NF-kappa B; SubVentricular Zone; Adult neural progenitor cells; HMGB-1; Adult neurogenesis; NF-KAPPA-B; HIPPOCAMPAL NEUROGENESIS; ALZHEIMERS-DISEASE; NEURITE OUTGROWTH; CEREBRAL-ISCHEMIA; AMYLOID-BETA; BRAIN-DAMAGE; STEM-CELLS; SIGNALING PATHWAYS; PROGRESSION FACTOR;

D O I：

10.1016/j.mcn.2010.06.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Receptor for Advanced Glycation End-products (RAGE) is a member of the immunoglobulin superfamily of cell surface receptors which interacts with a wide range of ligands, such as High-Mobility Group Box-1 (HMGB-1), S100B, advanced glycation end-products (AGEs). Here we provided evidence for the restricted expression of RAGE in the undifferentiated neural stem/progenitor cells of mouse adult SubVentricular Zone (SVZ) neurogenic region and adult SVZ-derived neurospheres. Additionally, RAGE ligands stimulated both proliferation and neuronal differentiation of SVZ-derived neural progenitor cells (NPC) in vitro. NF-kappa B nuclear translocation occurred upon RAGE activation in SVZ-derived neurospheres and its blockade (by SN-50) or its absence (in p50(-/-) derived NPC) resulted in the inhibition of the ligand-mediated effects on neuronal differentiation. These novel findings delineate an interesting scenario where the RAGE-NF-kappa B axis may contribute to regulate adult neural stem/progenitor cell function in physiological and possibly pathological conditions where this axis is upregulated. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：139 / 150

页数：12

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