Repression of protein synthesis by miRNAs: how many mechanisms?

被引：889

作者：

Pillai, Ramesh S.

Bhattacharyya, Suvendra N.

Filipowicz, Witold

机构：

[1] European Mol Biol Lab, Grenoble Outstn, F-38042 Grenoble 9, France

[2] Friedrich Miescher Inst, CH-4002 Basel, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.tcb.2006.12.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs are similar to 21-nucleotide-long regulators of gene expression that gain access to their target mRNAs by complementary base pairing. Recent studies have revealed that animal microRNAs might take diverse routes to repress gene expression, affecting both target mRNA levels and translation. Mechanistic details of microRNA-mediated repression are starting to emerge but a comprehensive picture of the inhibition, and particularly the effects on mRNA translation, is still lacking. Recent data support different microRNA mechanisms and a role for cytoplasmic processing bodies in the degradation and storage of mRNAs targeted by microRNA regulators.

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收藏

页码：118 / 126

页数：9

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