Life and death of the pancreatic β cells

被引：244

作者：

Bonner-Weir, S ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1043-2760(00)00305-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pancreatic beta cells are responsible for maintaining the body's glucose levels within a very narrow range; their population is dynamic, with compensatory changes to maintain euglycemia Throughout the lifetime of a mammal, low levels of beta -cell replication and apoptosis are balanced and result in a slowly increasing mass of beta cells. The emphasis in this review is on recent insights on the natural history of the beta cell in a normal pancreas: sources of renewal, survival and changes in differentiation.

引用

收藏

页码：375 / 378

页数：4

相关论文

共 60 条

[1]

Ahlgren U, 1996, DEVELOPMENT, V122, P1409

[2] Sustained proliferation of PDX-1+ cells derived from human islets [J].

Beattie, GM ;

Itkin-Ansari, P ;

Cirulli, V ;

Leibowitz, G ;

Lopez, AD ;

Bossie, S ;

Mally, MI ;

Levine, F ;

Hayek, A .

DIABETES, 1999, 48 (05) :1013-1019

[3] Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium [J].

Block, GD ;

Locker, J ;

Bowen, WC ;

Petersen, BE ;

Katyal, S ;

Strom, SC ;

Riley, T ;

Howard, TA ;

Michalopoulos, GK .

JOURNAL OF CELL BIOLOGY, 1996, 132 (06) :1133-1149

[4] POTENT INHIBITORY EFFECTS OF TRANSPLANTABLE RAT GLUCAGONOMAS AND INSULINOMAS ON THE RESPECTIVE ENDOGENOUS ISLET CELLS ARE ASSOCIATED WITH PANCREATIC APOPTOSIS [J].

BLUME, N ;

SKOUV, J ;

LARSSON, LI ;

HOLST, JJ ;

MADSEN, OD .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2227-2235

[5]

Bonner-Weir S, 1999, DIABETES, V48, pA3

[6] In vitro cultivation of human islets from expanded ductal tissue [J].

Bonner-Weir, S ;

Taneja, M ;

Weir, GC ;

Tatarkiewicz, K ;

Song, KH ;

Sharma, A ;

O'Neil, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7999-8004

[7]

Bonner-Weir S, 1997, TISS ENG, P138

[8] Islet growth and development in the adult [J].

Bonner-Weir, S .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2000, 24 (03) :297-302

[9]

BONNERWEIR S, 1994, RECENT PROG HORM RES, V49, P91

[10] A 2ND PATHWAY FOR REGENERATION OF ADULT EXOCRINE AND ENDOCRINE PANCREAS - A POSSIBLE RECAPITULATION OF EMBRYONIC-DEVELOPMENT [J].

BONNERWEIR, S ;

BAXTER, LA ;

SCHUPPIN, GT ;

SMITH, FE .

DIABETES, 1993, 42 (12) :1715-1720

← 1 2 3 4 5 6 →