Messages from the German Multicentre Allergy Study

被引：58

作者：

Nickel, R ^{[1
]}

Lau, S

Niggemann, B

Grüber, C

von Mutius, E

Illi, S

Kulig, M

Wahn, U

机构：

[1] Charite, Dept Pediat Pneumol & Immunol, Berlin, Germany

[2] Univ Childrens Hosp Dr von Hauner, Munich, Germany

[3] Humboldt Univ, Charite Inst Social Med Epidemiol & Hlth Econ, D-1086 Berlin, Germany

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2002年 / 13卷

关键词：

asthma; atopy; birth cohort; MAS;

D O I：

10.1034/j.1399-3038.13.s.15.4.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Several birth cohort studies have been initiated during the past two decades to study environmental and genetic risk factors for atopic dermatitis, asthma and allergic rhinitis. This article summarizes results from the German Multicentre Allergy Study (MAS), which has followed children (initially 1314) from birth (in 1990) to the present time. The effects of immunizations, allergen exposure, early sensitization patterns as well as upper airway infections on the subsequent development of asthma and atopy at school age are described. Furthermore, candidate gene studies of atopic dermatitis and increased total serum IgE levels on chromosomes 5q, 12q and 17q in MAS-children and their parents are outlined.

引用

页码：7 / 10

页数：4

共 15 条

[1]

Bergmann R L, 1994, Pediatr Allergy Immunol, V5, P19, DOI 10.1111/j.1399-3038.1994.tb00343.x

[2] Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers [J].

Beyer, K ;

Nickel, R ;

Freidhoff, L ;

Björkstén, B ;

Huang, SK ;

Barnes, KC ;

MacDonald, S ;

Forster, J ;

Zepp, F ;

Wahn, V ;

Beaty, TH ;

Marsh, DG ;

Wahn, U .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 115 (05) :906-908

[3] A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children [J].

Graves, PE ;

Kabesch, M ;

Halonen, M ;

Holberg, CJ ;

Baldini, M ;

Fritzsch, C ;

Weiland, SK ;

Erickson, RP ;

von Mutius, E ;

Martinez, FD .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (03) :506-513

[4] Delayed hypersensitivity to tuberculin, total immunoglobulin E, specific sensitization, and atopic manifestation in longitudinally followed early bacille Calmette-Gue'rin-vaccinated and nonvaccinated children [J].

Grüber, C ;

Kulig, M ;

Bergmann, R ;

Guggenmoos-Holzmann, I ;

Wahn, U .

PEDIATRICS, 2001, 107 (03) :E36

[5] Genetic variants of IL-13 signalling and human asthma and atopy [J].

Heinzmann, A ;

Mao, XQ ;

Akaiwa, M ;

Kreomer, RT ;

Gao, PS ;

Ohshima, K ;

Umeshita, R ;

Abe, Y ;

Braun, S ;

Yamashita, T ;

Roberts, MH ;

Sugimoto, R ;

Arima, K ;

Arinobu, Y ;

Yu, B ;

Kruse, S ;

Enomoto, T ;

Dake, Y ;

Kawai, M ;

Shimazu, S ;

Sasaki, S ;

Adra, CN ;

Kitaichi, M ;

Inoue, H ;

Yamauchi, K ;

Tomichi, N ;

Kurimoto, F ;

Hamasaki, N ;

Hopkin, JM ;

Izuhara, K ;

Shirakawa, T ;

Deichmann, KA .

HUMAN MOLECULAR GENETICS, 2000, 9 (04) :549-559

[6] Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study [J].

Illi, S ;

von Mutius, E ;

Lau, S ;

Bergmann, R ;

Niggemann, B ;

Sommerfeld, C ;

Wahn, U .

BMJ-BRITISH MEDICAL JOURNAL, 2001, 322 (7283) :390-395

[7] The pattern of atopic sensitization is associated with the development of asthma in childhood [J].

Illi, S ;

von Mutius, E ;

Lau, S ;

Nickel, R ;

Niggermann, B ;

Sommerfeld, C ;

Wahn, U .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :709-714

[8] Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study [J].

Lau, S ;

Illi, S ;

Sommerfeld, C ;

Niggemann, B ;

Bergmann, R ;

von Mutius, E ;

Wahn, U .

LANCET, 2000, 356 (9239) :1392-1397

[9]

Le Souëf PN, 2000, LANCET, V356, P242

[10] An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German Multicenter Atopy Study (MAS-90) [J].

Liu, X ;

Nickel, R ;

Beyer, K ;

Wahn, U ;

Ehrlich, E ;

Freidhoff, LR ;

Björkstén, B ;

Beaty, TH ;

Huang, SK .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (01) :167-170

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