Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease

被引:109
作者
Boska, Michael D.
Hasan, Khader M.
Kibuule, Danette
Banerjee, Rebecca
McIntyre, Erin
Nelson, Jay A.
Hahn, Theresa
Gendelman, Howard E.
Mosley, R. Lee
机构
[1] Univ Nebraska, Med Ctr, Dept Radiol, Omaha, NE 68198 USA
[2] Univ Nebraska Med Ctr, Ctr Neurovirol & Neurodegenerat Disorders, Omaha, NE 68198 USA
[3] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA
[4] Univ Nebraska Med Ctr, Dept Internal Med, Omaha, NE 68198 USA
[5] Univ Texas, Med Sch, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA
关键词
Parkinson's disease; diffusion tensor imaging; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP; substantia nigra; striatum; dopaminergic neurons;
D O I
10.1016/j.nbd.2007.02.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Early diagnosis of Parkinson's disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect >50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p<0.005) and decreased fractional anisotropy (P<0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences (p <= 0.002) and correlated with the numbers of SN dopaminergic neurons (r=-0.75, p=0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:590 / 596
页数:7
相关论文
共 34 条
[1]   ESTIMATION OF THE EFFECTIVE SELF-DIFFUSION TENSOR FROM THE NMR SPIN-ECHO [J].
BASSER, PJ ;
MATTIELLO, J ;
LEBIHAN, D .
JOURNAL OF MAGNETIC RESONANCE SERIES B, 1994, 103 (03) :247-254
[2]   The basis of anisotropic water diffusion in the nervous system - a technical review [J].
Beaulieu, C .
NMR IN BIOMEDICINE, 2002, 15 (7-8) :435-455
[3]  
Benamer HTS, 2000, MOVEMENT DISORD, V15, P692, DOI 10.1002/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO
[4]  
2-V
[5]  
BERNHEIMER H, 1973, J NEUROL SCI, V20, P415, DOI 10.1016/0022-510X(73)90175-5
[6]   Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease [J].
Boska, MD ;
Lewis, TB ;
Destache, CJ ;
Benner, EJ ;
Nelson, JA ;
Uberti, M ;
Mosley, RL ;
Gendelman, HE .
JOURNAL OF NEUROSCIENCE, 2005, 25 (07) :1691-1700
[7]  
BOSKA MD, 2003, 11 SCI M EXH INT SOC, P4
[8]   Functional imaging in Parkinson's disease: activation studies with PET, fMRI and SPECT [J].
Ceballos-Baumann, AO .
JOURNAL OF NEUROLOGY, 2003, 250 (Suppl 1) :15-23
[9]   Proton MR spectroscopic imaging of the striatum in Parkinson's disease [J].
Cruz, CJ ;
Aminoff, MJ ;
Meyerhoff, DJ ;
Graham, SH ;
Weiner, MW .
MAGNETIC RESONANCE IMAGING, 1997, 15 (06) :619-624
[10]   EARLY DIFFERENTIAL-DIAGNOSIS OF PARKINSONS-DISEASE WITH F-18 FLUORODEOXYGLUCOSE AND POSITRON EMISSION TOMOGRAPHY [J].
EIDELBERG, D ;
MOELLER, JR ;
ISHIKAWA, T ;
DHAWAN, V ;
SPETSIERIS, P ;
CHALY, T ;
BELAKHLEF, A ;
MANDEL, F ;
PRZEDBORSKI, S ;
FAHN, S .
NEUROLOGY, 1995, 45 (11) :1995-2004