The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C-elegans

被引：499

作者：

Apfeld, J ^{[1
]}

O'Connor, G ^{[1
]}

McDonagh, T ^{[1
]}

DiStefano, PS ^{[1
]}

Curtis, R ^{[1
]}

机构：

[1] Elixir Pharmaceut, Cambridge, MA 02139 USA

来源：

GENES & DEVELOPMENT | 2004年 / 18卷 / 24期

关键词：

aging; C; elegans; AMPK; insulin signaling; FOXO; energy levels;

D O I：

10.1101/gad.1255404

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although limiting energy availability extends lifespan in many organisms, it is not understood how lifespan is coupled to energy levels. We find that the AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C. elegans AMP-activated protein kinase alpha subunit AAK-2 is activated by AMP and functions to extend lifespan. In addition, either an environmental stressor that increases the AMP:ATP ratio or mutations that lower insulin-like signaling extend lifespan in an aak-2-dependent manner. Thus, AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals.

引用

页码：3004 / 3009

页数：6

共 36 条

[1] AMP-activated protein kinase plays a role in the control of food intake [J].