The uncoupling protein, thermogenin

被引：100

作者：

Palou, A ^{[1
]}

Picó, C ^{[1
]}

Bonet, ML ^{[1
]}

Oliver, P ^{[1
]}

机构：

[1] Univ Illes Balears, Dept Biol Fonamental & Ciencies Salut, Lab Biol Mol Nutr & Biotecnol, E-07071 Palma de Mallorca, Spain

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1998年 / 30卷 / 01期

关键词：

uncoupling protein; thermogenin; UCP; UCP2; obesity; thermogenesis;

D O I：

10.1016/S1357-2725(97)00065-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The uncoupling protein (UCP) or thermogenin is a 33 kDa inner-membrane mitochondrial protein exclusive to brown adipocytes in mammals that functions as a proton transporter, allowing the dissipation as heat of the proton gradient generated by the respiratory chain and thereby uncoupling oxidative phosphorylation. Thermogenesis (heat production) in brown adipose tissue, which is activated in response to cold exposure or chronic overeating, depends largely on UCP activity. Norepinephrine, released from sympathetic terminals and acting via beta-adrenoceptors and cAMP, is the main positive regulator of both UCP synthesis and activity. Brown fat thermogenesis plays a critical role in thermoregulation and in overall energy balance, at least in rodents. Manipulation of thermogenesis, whether through UCP or through analogous uncoupling proteins, could be an effective strategy against obesity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7 / 11

页数：5

共 17 条

[1] SELECTIVE LOSS OF THE UNCOUPLING PROTEIN FROM LIGHT VERSUS HEAVY MITOCHONDRIA OF BROWN ADIPOCYTES AFTER A DECREASE IN NORADRENERGIC STIMULATION IN-VIVO AND IN-VITRO [J].