Haemostatic alterations in colorectal cancer: Perspectives for future treatment

被引：14

作者：

Lykke, J ^{[1
]}

Nielsen, HJ ^{[1
]}

机构：

[1] Hvidovre Univ Hosp, Dept Surg Gastroenterol 435, Surg Immunol Lab, Copenhagen, Denmark

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2004年 / 88卷 / 04期

关键词：

colorectal cancer; fibrinolysis; coagulation; tissue factor; surgery; infectious complications;

D O I：

10.1002/jso.20158

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of the haemostatic system in colorectal cancer (CRC) is reviewed. Correlations between the activation of the haemostatic system and overall survival have been suggested. Experimental studies indicate that the haemostatic system plays a key role in growth, invasion and dissemination of tumour cells, and in tumour related angiogenesis. Additional activation by the surgical trauma and postoperative infections are discussed. Finally, anti-cancer modalities directed against regulation of the haemostatic system in CRC are considered. (C) 2004 Wiley-Liss, Inc.

引用

页码：269 / 275

页数：7

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