The pathogenic role of tissue-resident immune cells in psoriasis

被引：106

作者：

Boyman, Onur ^{[1
]}

Conrad, Curdin

Tonel, Giulia

Gilliet, Michel

Nestle, Frank O.

机构：

[1] Univ Lausanne Hosp CHUV, Div Immunol & Allergy, CH-1011 Lausanne, Switzerland

[2] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland

[3] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[4] Kings Coll London, Sch Med, Div Med & Mol Genet, St Johns Inst Dermatol, London SE1 9RT, England

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 02期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

NECROSIS-FACTOR-ALPHA; CHRONIC PLAQUE PSORIASIS; DERMAL DENDRITIC CELLS; NORMAL HUMAN-SKIN; T-CELLS; RHEUMATOID-ARTHRITIS; RANDOMIZED-TRIAL; AUTOIMMUNE-DISEASE; IMPROVES PSORIASIS; INTERFERON-GAMMA;

D O I：

10.1016/j.it.2006.12.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is a common chronic inflammatory skin disease, the study of which might also be of considerable value to the understanding of other inflammatory and autoimmune-type diseases, such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and diabetes mellitus. There is clear evidence that T cells and dendritic cells have a central role in psoriasis. Based on recent data from humans and animal models, we propose that a psoriasis lesion can be triggered and sustained by the local network of skin-resident immune cells. This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases.

引用

页码：51 / 57

页数：7

共 79 条

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