Two mirror-image sensory maps with domain organization in the mouse main olfactory bulb

被引：74

作者：

Nagao, H

Yoshihara, Y

Mitsui, S

Fujisawa, H

Mori, K ^{[1
]}

机构：

[1] RIKEN, Brain Sci Inst, Lab Neuronal Recognit Mol, Wako, Saitama 3510198, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Physiol, Tokyo 1130033, Japan

[3] Nagoya Univ, Grad Sch Sci, Dept Biol Sci, Nagoya, Aichi 4648602, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 13期

关键词：

cell adhesion molecule; neuropilin-I; OCAM; odorant receptor; olfactory bulb; sensory map;

D O I：

10.1097/00001756-200009110-00039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The glomerular sheet in the olfactory bulb (OB) provides an olfactory sensory map identifying which odorant receptors (ORs) in the nose are activated by inhaled odorants. How are the glomeruli spatially arranged in the OB? Using OCAM and neuropilin-1 (NPI) as molecular markers for target glomeruli of distinct subsets of olfactory axons, we demonstrate here that glomeruli are parceled into topographically distinct domains. Spatial arrangement of these domains suggests that each OB contains two mirror-image maps of the glomeruli. In situ hybridization shows that the glomeruli representing the same OR are symmetrically arranged; one in a domain in the lateral hemisphere and the other in a corresponding domain in the medial hemisphere of the OB. These results suggest that OB contains two symmetrical OR maps with similar domain organization. NeuroReport 11:3023-3027 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3023 / 3027

页数：5

共 26 条

[1] A map of pheromone receptor activation in the mammalian brain [J].