Remarkable roles of proteolysis on and beyond the cell surface

被引：210

作者：

Blobel, CP ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Cellular Biochem & Biophys Program, New York, NY 10021 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(00)00139-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EG F-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.

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页码：606 / 612

页数：7

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