Chromatin modifications and their function

被引：8266

作者：

Kouzarides, Tony

机构：

[1] Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QN, England

来源：

CELL | 2007年 / 128卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA. In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited. © 2007 Elsevier Inc. All rights reserved.

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页码：693 / 705

页数：13

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