Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells

被引:29
作者
Aiura, K
Clark, BD
Dinarello, CA
Margolis, NH
Kaplanski, G
Burke, JF
Tompkins, RG
Gelfand, JA
机构
[1] TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,BOSTON,MA 02111
[2] TUFTS UNIV,SCH MED,DEPT MED,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111
[3] HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA
[4] MASSACHUSETTS GEN HOSP,BOSTON,MA 02114
关键词
D O I
10.1093/infdis/175.1.123
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effect of activated platelets on cytokine production by human peripheral blood mononuclear cells (PBMC) was investigated. When PBMC were coincubated with activated autologous platelets amid lipopolysaccharide (LPS, 50-100 pg/mL) for 8 h, the production of interleukin (IL)-1 alpha increased 11- to 18-fold and tumor necrosis factor (TNF)-alpha 3- to 5-fold compared with PBMC without platelets. Activated platelets in a dual-chamber well that prevented platelet-PBMC contact but permitted passage of soluble factors enhanced IL-1 alpha production (P < .01). Platelet-PBMC contact in the chamber resulted in a further enhancement of IL-1 alpha production. These data suggest that platelet-PBMC interaction, both directly and with platelet-derived factors, enhances production of shock-producing IL-1 alpha and TNF-alpha, albeit differently. The interaction of platelets with monocytes may play an important role in the pathophysiology of sepsis and disseminated intravascular coagulation.
引用
收藏
页码:123 / 129
页数:7
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