Novel IL-12 family members shed light on the orchestration of Th1 responses

被引：233

作者：

Brombacher, F

Kastelein, RA

Alber, G

机构：

[1] Univ Leipzig, Coll Vet Med, Inst Immunol, D-04103 Leipzig, Germany

[2] Univ Cape Town, Groote Schuur Hosp, Div Immunol, ZA-7925 Cape Town, South Africa

[3] DNAX Res Inst Molec & Cellular Biol Inc, Palo Alto, CA 94304 USA

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1471-4906(03)00067-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produced in excess. Besides IL-12, other p40-dependent molecules exist that orchestrate Th1 responses. Homodimeric p40 can act as an IL-12 antagonist by competing for its receptor. Recent data also reveal potential immunostimulatory functions of p40. In addition, p40 can be covalently linked to a p35-related protein p19. This heterodimer is known as IL-23 and has activities on memory T cells. Finally, IL-27, the latest addition to this family, is a heterodimer composed of the p40-related protein EBI3 (Epstein-Barr virus-induced gene 3) and the p35-related protein p28. IL-27 is involved in early Th1 initiation.

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页码：207 / 212

页数：6

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