TH1 cells control themselves by producing interleukin-10

被引：495

作者：

O'Garra, Anne

Vieira, Paulo

机构：

[1] Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

[2] Inst Pasteur, Unite Dev Lymphocytes, F-75724 Paris 15, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nri2097

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.

引用

收藏

页码：425 / 428

页数：4

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