Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter

被引：531

作者：

Heinz, A

Braus, DF

Smolka, MN

Wrase, J

Puls, I

Hermann, D

Klein, S

Grüsser, SM

Flor, H

Schumann, G

Mann, K

Büchel, C

机构：

[1] Charite Univ Med Berlin, Dept Psychiat, D-10117 Berlin, Germany

[2] Univ Med Ctr, Dept Psychiat, NeuroImage Nord, D-20246 Hamburg, Germany

[3] Cent Inst Mental Hlth, D-68159 Mannheim, Germany

[4] Charite Univ Med Berlin, Dept Med Psychol, D-10117 Berlin, Germany

[5] Univ Med Ctr, Dept Neurol, NeuroImage Nord, D-20246 Hamburg, Germany

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 01期

关键词：

D O I：

10.1038/nn1366

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression.

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页码：20 / 21

页数：2

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