Immunological ignorance of silent antigens as an explanation of tumor evasion

被引：80

作者：

Chen, LP

机构：

[1] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA

[2] Bristol Myers Squibb Pharmaceut Res Inst, Seattle, WA 98121 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(97)01180-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although there is little doubt about the existence of tumor antigens that can be recognized by cytotoxic T lymphocytes in common human cancers, it is still unclear why these antigens do not cause tumor rejection. Here, Lieping Chen proposes that immunological ignorance of silent antigens might explain the inefficient T-cell response to cancer, and suggests how this may be overcome.

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页码：27 / 30

页数：4

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