Rasminogen activator inhibitor-1, adipose tissue and insulin resistance

被引：163

作者：

Alessi, Marie-Christine ^{[1
]}

Poggi, Marjorie ^{[1
]}

Juhan-Vague, Irene ^{[1
]}

机构：

[1] Fac Med Marseille, INSERM, UMR 626, Hematol Lab, F-13385 Marseille 5, France

来源：

CURRENT OPINION IN LIPIDOLOGY | 2007年 / 18卷 / 03期

关键词：

adipose tissue; atherothrombosis; metabolic syndrome; obesity; plasminogen activator inhibitor-1;

D O I：

10.1097/MOL.0b013e32814e6d29

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose of review Plasminogen activator inhibitor (PAI)-1 is a physiological inhibitor of plasminogen activators (urokinase and tissue types) and vitronectin. It is synthesized by adipose tissue, and its levels in plasma are increased in obesity and reduced with weight loss. Circulating PAI-1 level predicts development of type 2 diabetes, suggesting that it may be causally related to development of obesity. A role for PAI-1 in development of obesity has only partially been established, however. This review summarizes current knowledge, gives context to developments thus far and discusses controversies. Recent findings, In addition to its role in atherothrombosis, PAI-1 might be involved in adipose tissue development. PAI-1 is produced by ectopic fat depots under the influence of inducers. Among the most recently described inducers are inflammation, oxidative stress and circadian clock protein. PAI-1 may play several roles in contributing to obesity: through indirect effects on insulin signalling, by influencing adipocyte differentiation and by regulating recruitment of inflammatory cells within adipose tissue. Summary These recent findings emphasize the involvement of PAH in controlling the biology of adipose tissue; PAI-1 is an attractive new therapeutic target to retard the metabolic complications that accompany obesity.

引用

页码：240 / 245

页数：6

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