Inhibition of ornithine decarboxylase by ifenprodil

被引：5

作者：

Badolo, L ^{[1
]}

Dubois, J ^{[1
]}

Helson-Cambier, M ^{[1
]}

Hanocq, M ^{[1
]}

机构：

[1] Free Univ Brussels, Inst Pharm, Lab Bioanalyt Chem Toxicol & Appl Phys Chem, B-1050 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 342卷 / 2-3期

关键词：

ifenprodil; ornithine decarboxylase; alpha-difluoromethylornithine;

D O I：

10.1016/S0014-2999(97)01601-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ifenprodil (NMDA receptor antagonist) was tested as an inhibitor of ornithine decarboxylase. It was found that ifenprodil inhibited ornithine decarboxylase activity with the same potency as alpha-difluoromethylornithine, a major inhibitor of ornithine decarboxylase. This result suggests that ifenprodil could target either the polyamine site on the NMDA receptor complex or/and polyamine biosynthesis. (C) 1998 Elsevier Science B.V.

引用

页码：R1 / R2

页数：2

共 4 条

[1] IFENPRODIL AND SL-82.0715 ARE ANTAGONISTS AT THE POLYAMINE SITE OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR [J].