Dopamine-receptor stimulation:: biobehavioral and biochemical consequences

被引：81

作者：

Calon, F

Tahar, AH

Blanchet, PJ

Morissette, M

Grondin, R

Goulet, M

Doucet, JP

Robertson, GS

Nestler, E

Di Paolo, T

Bédard, P

机构：

[1] Univ Laval, Med Ctr, CHUL, Oncol & Mol Endocrinol Res Unit, Quebec City, PQ G1V 4G2, Canada

[2] Univ Laval, Fac Pharm, St Foy, PQ G1K 7P4, Canada

[3] Univ Laval, Med Ctr, CHUL, Neurosci Res Unit, Quebec City, PQ G1V 4G2, Canada

[4] Univ Laval, Fac Med, Dept Med, St Foy, PQ G1K 7P4, Canada

[5] Univ Ottawa, Fac Med, Dept Pharmacol, Ottawa, ON, Canada

[6] Connecticut Mental Hlth Ctr, New Haven, CT 06508 USA

[7] Yale Univ, Sch Med, Lab Mol Psychiat, New Haven, CT 06508 USA

[8] Yale Univ, Sch Med, Yale Ctr Genes & Behav, New Haven, CT 06508 USA

来源：

TRENDS IN NEUROSCIENCES | 2000年 / 23卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1471-1931(00)00026-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that L-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (nonphysiological) stimulation of dopamine receptors, which activates se cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the Delta FosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.

引用

页码：S92 / S100

页数：9

共 117 条

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