Molecular mimicry in the MHC. Hidden clues to autoimmunity?

被引：79

作者：

Baum, H ^{[1
]}

Davies, H ^{[1
]}

Peakman, M ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL, SCH MED & DENT, DEPT IMMUNOL, LONDON SE5 9PJ, ENGLAND

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 02期

关键词：

D O I：

10.1016/0167-5699(96)80581-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The term 'molecular mimicry' has been used to describe a spectrum of antigenic crossreactivities thought to underlie autoimmune disease. For T-cell crossreactivities to occur, appropriate T-cell clones must be available. Here, Harold Baum, Huw Davies and Mark Peakman speculate that an important source of self-peptides that govern thymic selection of such clones are MHC molecules themselves.

引用

页码：64 / 70

页数：7

共 46 条

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