New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor

被引：98

作者：

Belofsky, GN ^{[1
]}

Jensen, PR ^{[1
]}

Renner, MK ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 09期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4020(97)10396-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new sesquiterpenoid nitrobenzoyl esters (1-4) have been isolated from organic extracts of the culture broth and mycelia of Aspergillus versicolor, a fungus isolated from the surface of the Caribbean green alga Penicillus capitatus. The structures of the four compounds were determined through extensive analysis of H-1 NMR, C-13 NMR, HMQC, and HMBC data. 9 alpha,14-Dihydroxy-6 beta-p-nitrobenzoylcinnamolide (1) displayed significant cytoxicity against HCT-116 human colon carcinoma cells in vitro and exhibited moderately selective cytotoxicity toward a panel of renal tumor cell lines. (C) 1998 Elsevier Science Ltd. Ali rights reserved.

引用

页码：1715 / 1724

页数：10

共 29 条

[1] DRIMANE SESQUITERPENE LACTONES FROM PENIOPHORA-POLYGONIA [J].