The role of oxidative damage and stress in aging

被引：449

作者：

Bokov, A

Chaudhuri, A

Richardson, A

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78229 USA

[3] Univ Texas, Hlth Sci Ctr, Dept Biochem, San Antonio, TX 78229 USA

[4] Univ Texas, Hlth Sci Ctr, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA

[5] S Texas Vet Hlth Care Syst, Ctr Geriatr Res Educ & Clin, San Antonio, TX 78284 USA

[6] S Texas Vet Hlth Care Syst, Res Serv, San Antonio, TX 78284 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 10-11期

基金：

美国国家卫生研究院;

关键词：

antioxidants; oxidative damage; oxidative stress; free radicals;

D O I：

10.1016/j.mad.2004.07.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at the biochemical/molecular level. However, most of the evidence in support of this theory is correlative, e.g., oxidative damage to various biomolecules increases with age, and caloric restriction, which increases life span and retards aging, reduces the age-related increase in oxidative damage to biomolecules. The most direct test of the Free Radical/Oxidative Stress Theory of Aging is to specifically alter the age-related increase in oxidative damage and determine how this alteration affects life span. For the first time, investigators can use genetically altered animals to test directly the role of oxidative damage in aging. In this manuscript, we critically review the past research in this area and discuss potential future research directions in testing the Free Radical/Oxidative Theory of Aging. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：811 / 826

页数：16

共 194 条

[1] Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans [J].