Manipulating the type 1 vs type 2 balance in type 1 diabetes

被引：27

作者：

Christen, U ^{[1
]}

von Herrath, MG ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Dept Dev Immunol, San Diego, CA 92121 USA

来源：

IMMUNOLOGIC RESEARCH | 2004年 / 30卷 / 03期

关键词：

chemokines; cytokines; CXCL10; TNF alpha; LCMV; autoimmunity; inflammation;

D O I：

10.1385/IR:30:3:309

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus infections cause a strong inflammatory reaction that is dominated by the expression of type 1 cytokines and chemokines. Such an aggressive immune response by the host is necessary to eliminate intracellular pathogens. However, because of this shift in the type 1 vs type 2 balance of the immune response, virus infections are potential candidates for triggering autoimmune diseases, such as type 1 diabetes (T1D), herpes stromal keratitis, or multiple sclerosis (MS). In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an agressive type 1-dominated immune response can be restrained and autoimmunity be abrogated.

引用

收藏

页码：309 / 325

页数：17

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