Apoptosis and nuclear factor-κB:: A tale of association and dissociation

被引：143

作者：

Aggarwal, BB ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Bioimmunotherapy, Houston, TX 77030 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2000年 / 60卷 / 08期

关键词：

NF-kappa B; apoptosis; caspases; reactive oxygen intermediates; TNF;

D O I：

10.1016/S0006-2952(00)00393-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It is not clear why on treatment with certain killer cytokines or chemotherapeutic agents, some cells undergo apoptosis while others do not. The delineation of sensitivity/resistance pathways should provide a more specific therapy for cancer and other hyperproliferative diseases. Most cells die either by apoptosis or by necrosis. The biochemical pathway that mediates these two modes of cell death has recently been described. The nuclear factor (NF)-kappa B and the genes regulated by this transcription factor have been shown to play a critical role in induction of resistance to killer agents. Thus, inhibitors of NF-kappa B activation have a potential in overcoming resistance to apoptosis induced by various agents. The evidence for and against such a notion is discussed. BIOCHEM PHARMACOL 60;8:1033-1039, 2000. (C) 2000 Elsevier Science Inc.

引用

页码：1033 / 1039

页数：7

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