Synthetic biology: Starting from scratch

被引:41
作者
Ball, P
机构
[1] consultant editor of Nature,
关键词
D O I
10.1038/431624a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Genetic engineering is old hat. Biologists are now synthesizing genomes, altering the genetic code and contemplating new life forms. Is it time to think about the risks? Philip Ball asks the experts.
引用
收藏
页码:624 / 626
页数:3
相关论文
共 11 条
[1]   Chemical synthesis of poliovirus cDNA: Generation of infectious virus in the absence of natural template [J].
Cello, J ;
Paul, AV ;
Wimmer, E .
SCIENCE, 2002, 297 (5583) :1016-1018
[2]  
*CIA OTI, 2001, 2003108 CIA OTI
[3]   Reprogramming control of an allosteric signaling switch through modular recombination [J].
Dueber, JE ;
Yeh, BJ ;
Chak, K ;
Lim, WA .
SCIENCE, 2003, 301 (5641) :1904-1908
[4]   A synthetic oscillatory network of transcriptional regulators [J].
Elowitz, MB ;
Leibler, S .
NATURE, 2000, 403 (6767) :335-338
[5]   Construction of a genetic toggle switch in Escherichia coli [J].
Gardner, TS ;
Cantor, CR ;
Collins, JJ .
NATURE, 2000, 403 (6767) :339-342
[6]   Engineering a mevalonate pathway in Escherichia coli for production of terpenoids [J].
Martin, VJJ ;
Pitera, DJ ;
Withers, ST ;
Newman, JD ;
Keasling, JD .
NATURE BIOTECHNOLOGY, 2003, 21 (07) :796-802
[7]   A GENERAL-METHOD FOR SITE-SPECIFIC INCORPORATION OF UNNATURAL AMINO-ACIDS INTO PROTEINS [J].
NOREN, CJ ;
ANTHONYCAHILL, SJ ;
GRIFFITH, MC ;
SCHULTZ, PG .
SCIENCE, 1989, 244 (4901) :182-188
[8]   Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms [J].
Park, SH ;
Zarrinpar, A ;
Lim, WA .
SCIENCE, 2003, 299 (5609) :1061-1064
[9]   Generating a synthetic genome by whole genome assembly:: φX174 bacteriophage from synthetic oligonucleotides [J].
Smith, HO ;
Hutchison, CA ;
Pfannkoch, C ;
Venter, JC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :15440-15445
[10]   ENZYMATIC INCORPORATION OF A NEW BASE PAIR INTO DNA AND RNA [J].
SWITZER, C ;
MORONEY, SE ;
BENNER, SA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (21) :8322-8323