Pathways to parkinsonism

被引：91

作者：

Cookson, MR ^{[1
]}

机构：

[1] Natl Inst Aging, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

来源：

NEURON | 2003年 / 37卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(02)01166-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, (x-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.

引用

页码：7 / 10

页数：4

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