WNT signalling and haematopoiesis: A WNT-WNT situation

被引：257

作者：

Staal, FJT

Clevers, HC

机构：

[1] Erasmus Med Ctr, Dept Immunol, NL-3015 GE Rotterdam, Netherlands

[2] Hubrecht Lab Dev Biol, Utrecht, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 01期

关键词：

D O I：

10.1038/nri1529

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

引用

收藏

页码：21 / 30

页数：10

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