The diagnostic role of Procalcitonin and other biomarkers in discriminating infectious from non-infectious fever

被引：256

作者：

Limper, M. ^{[1
,2
]}

de Kruif, M. D. ^{[1
]}

Duits, A. J. ^{[2
]}

Brandjes, D. P. M. ^{[1
]}

van Gorp, E. C. M. ^{[1
,3
]}

机构：

[1] Slotervaart Hosp, Dept Internal Med, NL-1066 EC Amsterdam, Netherlands

[2] Red Cross Blood Bank Fdn, Immunol Lab Dept, Willemstad, Curacao, Neth Antilles

[3] Erasmus MC, Dept Virol, Rotterdam, Netherlands

来源：

JOURNAL OF INFECTION | 2010年 / 60卷 / 06期

关键词：

Fever; Biological markers; Autoimmune diseases; C-reactive protein; Procalcitonin; C-REACTIVE PROTEIN; FAMILIAL-MEDITERRANEAN-FEVER; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYOCARDIAL-INFARCTION; INFLAMMATORY-BOWEL-DISEASE; TUMOR-NECROSIS-FACTOR; ACUTE-PHASE RESPONSE; SERUM PROCALCITONIN; BACTERIAL-INFECTION; PULMONARY-EMBOLISM;

D O I：

10.1016/j.jinf.2010.03.016

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Fever is not only observed in the course of a bacterial or viral infection, but can be a symptom of, for instance, auto-immune, malignant or thromboembolic disease. Determining the etiology of fever in a fast and reliable way is of pivotal importance, as different causes of fever may ask for different therapies. Neither clinical signs and symptoms, nor traditional biomarkers, such as CRP, leukocytes and ESR have sufficient sensitivity and specificity to guide treatment decisions. In this review we focus on the value of traditional and newer biomarkers in non-infectious febrile diseases. Procalcitonin (PCT) seems to be the most helpful laboratory marker for the differentiation of causes of fever, particularly in autoimmune, autoinflammatory and malignant diseases. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：409 / 416

页数：8

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