Neuropharmacology - Premenstrual steroids?

被引：19

作者：

Britton, KT ^{[1
]}

Koob, GF

机构：

[1] Vet Adm Med Ctr, Dept Psychiat, San Diego, CA 92161 USA

[2] Univ Calif San Diego, San Diego, CA 92161 USA

[3] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA

来源：

NATURE | 1998年 / 392卷 / 6679期

关键词：

D O I：

10.1038/31816

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The symptoms of premenstrual syndrome include depressed mood and anxiety, and the molecular mechanisms behind this are now becoming clear. During menstruation, levels of progesterone fall, and, as a result, so do levels of the progesterone metabolite allopregnanolone. Using a rat model, the authors have found that when production of allopregnanolone is blocked, increased levels of the α4 subunit of the GABAAreceptor are produced. This changes the sensitivity of the receptor to endogenous ligands, resulting in the symptoms associated with premenstrual syndrome.

引用

页码：869 / 870

页数：2

共 19 条

[1] The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations [J].

Barbaccia, ML ;

Roscetti, G ;

Trabucchi, M ;

Purdy, RH ;

Mostallino, MC ;

Concas, A ;

Biggio, G .

BRITISH JOURNAL OF PHARMACOLOGY, 1997, 120 (08) :1582-1588

[2]

BAULIEU EE, 1981, STEROID HORMONE REGU, P3014

[3] Premenstrual syndrome: Evidence for symptom stability across cycles [J].

Bloch, M ;

Schmidt, PJ ;

Rubinow, DR .

AMERICAN JOURNAL OF PSYCHIATRY, 1997, 154 (12) :1741-1746

[4] The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with GABA(A) receptors [J].

Brot, MD ;

Akwa, Y ;

Purdy, RH ;

Koob, GF ;

Britton, KT .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 325 (01) :1-7

[5] THE NEUROSTEROID, 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE, PROTECTS AGAINST BICUCULLINE-INDUCED SEIZURES DURING ETHANOL WITHDRAWAL IN RATS [J].

DEVAUD, LL ;

PURDY, RH ;

MORROW, AL .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1995, 19 (02) :350-355

[6] PREGNENOLONE SULFATE ENHANCES POST-TRAINING MEMORY PROCESSES WHEN INJECTED IN VERY-LOW DOSES INTO LIMBIC SYSTEM STRUCTURES - THE AMYGDALA IS BY FAR THE MOST SENSITIVE [J].

FLOOD, JF ;

MORLEY, JE ;

ROBERTS, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10806-10810

[7]

GEE KW, 1995, CRIT REV NEUROBIOL, V9, P207

[8] STEROID-HORMONE METABOLITES ARE BARBITURATE-LIKE MODULATORS OF THE GABA RECEPTOR [J].

MAJEWSKA, MD ;

HARRISON, NL ;

SCHWARTZ, RD ;

BARKER, JL ;

PAUL, SM .

SCIENCE, 1986, 232 (4753) :1004-1007

[9] Diagnostic and Statistical Manual of Mental Disorders [J].

Mittal, Vijay A. ;

Walker, Elaine F. .

PSYCHIATRY RESEARCH, 2011, 189 (01) :158-159

[10] Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids [J].

Park-Chung, M ;

Wu, FS ;

Purdy, RH ;

Malayev, AA ;

Gibbs, TT ;

Farb, DH .

MOLECULAR PHARMACOLOGY, 1997, 52 (06) :1113-1123

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