Regulation of IL-9 expression by IL-25 signaling

被引：183

作者：

Angkasekwinai, Pornpimon ^{[1
,2
,3
]}

Chang, Seon Hee ^{[1
,2
]}

Thapa, Manoj ^{[1
,2
]}

Watarai, Hiroshi ^{[4
]}

Dong, Chen ^{[1
,2
]}

机构：

[1] Univ Texas, Dept Immunol, Houston, TX USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[3] Thammasat Univ, Dept Med Technol, Fac Allied Hlth Sci, Pathum Thani, Thailand

[4] RIKEN, Res Ctr Allergy & Immunol, Lab Immune Regulat, Kanagawa, Japan

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 03期

关键词：

ALLERGIC AIRWAY INFLAMMATION; PULMONARY INFLAMMATION; T-HELPER-2; CELLS; IMMUNE-RESPONSES; ADAPTER PROTEIN; TRANSGENIC MICE; T-LYMPHOCYTES; TGF-BETA; IN-VIVO; HYPERRESPONSIVENESS;

D O I：

10.1038/ni.1846

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25. Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral overexpression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression.

引用

页码：250 / U9

页数：8

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