Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhages

被引:127
作者
Wong, KS
Chan, YL
Liu, JY
Gao, S
Lam, WWM
机构
[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Diagnost Radiol & Organ Imaging, Shatin, Hong Kong, Peoples R China
关键词
D O I
10.1212/01.WNL.0000046583.40125.20
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors measured the presence and extent of asymptomatic microbleeds on gradient-recalled-echo MRI in 21 aspirin users who developed intracerebral hemorrhage and 21 aspirin users without history of intracerebral hemorrhage. Microbleeds were more frequent (19 vs 7, p < 0.001) and more extensive (mean number of microbleeds 13.3 vs 0.4, p < 0.001) in the intracerebral hemorrhage group than in the control group. Asymptomatic microbleeds may be a risk factor for aspirin-associated intracerebral hemorrhage.
引用
收藏
页码:511 / 513
页数:3
相关论文
共 8 条
[1]   Miliary aneurysms in the brain [J].
Green, FHK .
JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1930, 33 (01) :71-77
[2]   Cerebral amyloid angiopathy - Prospects for clinical diagnosis and treatment [J].
Greenberg, SM .
NEUROLOGY, 1998, 51 (03) :690-694
[3]   MRI detection of new hemorrhages: Potential marker of progression in cerebral amyloid angiopathy [J].
Greenberg, SM ;
O'Donnell, HC ;
Schaefer, PW ;
Kraft, E .
NEUROLOGY, 1999, 53 (05) :1135-1138
[4]   Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke - A gradient-echo T2*-weighted brain MRI study [J].
Nighoghossian, N ;
Hermier, M ;
Adeleine, P ;
Blanc-Lasserre, K ;
Derex, L ;
Honnorat, J ;
Philippeau, F ;
Dugor, JF ;
Froment, JC ;
Trouillas, P .
STROKE, 2002, 33 (03) :735-742
[5]   Magnetic resonance imaging of cerebral microbleeds [J].
Roob, G ;
Fazekas, F .
CURRENT OPINION IN NEUROLOGY, 2000, 13 (01) :69-73
[6]   Warfarin-associated hemorrhage and cerebral amyloid angiopathy - A genetic and pathologic study [J].
Rosand, J ;
Hylek, EM ;
O'Donnell, HC ;
Greenberg, SM .
NEUROLOGY, 2000, 55 (07) :947-951
[7]  
Tokuda Y, 1999, JAMA-J AM MED ASSOC, V282, P732
[8]   Aspirin-associated intracerebral hemorrhage - Clinical and radiologic features [J].
Wong, KS ;
Mok, V ;
Lam, WWM ;
Kay, R ;
Tang, A ;
Chan, YL ;
Woo, J .
NEUROLOGY, 2000, 54 (12) :2298-2301