Control of experimental inflammatory bowel disease by regulatory T cells

被引：54

作者：

Asseman, C ^{[1
]}

Fowler, S ^{[1
]}

Powrie, F ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2000年 / 162卷 / 04期

关键词：

D O I：

10.1164/ajrccm.162.supplement_3.15tac9

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immunodeficient mice after transfer of CD45RB(high)CD4(+) T cells. Development of disease can be prevented by cotransfer of the reciprocal CD45RB(low) subset. Analysis of the mechanism of immune suppression transferred by CD45RB(low)CD4(+) cells revealed essential roles for both IL-10 and TGF-beta. These data indicate that a functionally specialized population of regulatory T (Treg) cells exists in normal mice and that these can prevent the development of pathogenic responses toward commensal bacteria. The role of Treg cells in the control of the immune response is discussed.

引用

页码：S185 / +

页数：6

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